<i>In Vitro, in Vivo</i> and <i>In Silico</i> Metabolic Profiling of α-Pyrrolidinopentiothiophenone, A Novel Thiophene Stimulant

Abstract

Seven α-PVT metabolites were identified in hepatocyte incubations, and in the authentic urine samples, also with an additional monohydroxylated product and a glucuronide of low intensity. α-PVT dihydroxypyrrolidinyl, α-PVT 2-ketopyrrolidinyl, α-PVT hydroxythiophenyl and α-PVT thiophenol had the most intense in vivo signals.