Type I Interferon Response Limits Astrovirus Replication and Protects against Increased Barrier Permeability <i>In Vitro</i> and <i>In Vivo</i>

Abstract

Human astroviruses are a major cause of pediatric diarrhea, yet little is known about the immune response. Here we show that type I interferon limits astrovirus infection and preserves barrier permeability both in vitro and in vivo. Importantly, we characterized a new mouse model for studying astrovirus replication and pathogenesis.