Bone Marrow–derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension

Abstract

Our data show that BM cells played a key role in PAH pathogenesis and that the transplanted BM cells were able to drive the lung phenotype in a myeloablative transplant model. Furthermore, the specific cell types involved were derived from hematopoietic stem cells and exhibit dysfunction long before the development of lung pathology.