Masking the unpleasant taste of etoricoxib by crosslinked acrylic polymer based ion-exchange resin complexation.

Abstract

Etoricoxib is an antiinflammatory and analgesic agent in the treatment of arthritis, dysmenorrhoea, acute dentalsurgerypain and is having a bitter taste. The present study is designed to mask the bitter taste of etoricoxib by complexation with weak cation exchange resins (Indion 214, 234 and 414) in order to increase its compatibility and patient compliance. Drug resinates were characterized by FTIR and XRD analysis methods. Drug resinates were evaluated by sensory taste evaluation test. Indion 234 resin was showing good taste masking ability compared to Indion 214 and 414. The in vitro drug release (after 60 minutes) was found to be 95%, 90% and 82% for F 234 III, F 414 III and F 214 respectively.