ANXIOLYTIC EFFECT OF CONVOLVULUS PLURICAULIS CHOISY PETALS ON ELEVATED PLUS MAZE MODEL OF ANXIETY IN MICE

Abstract

Convolvulus pluricaulis Choisy, one of traditional Medhya Rasayana drug has been acclaimed to have antianxiety effect in Ayurveda, an Indian system of medicine. This drug has been used for years as a brain tonic in the treatment of various neurological diseases but a scientific evaluation of its effect is still lacking. Evidences have demonstrated that the activity of plant is maximum during flowering season. Based on this extract of Convolvulus pluricaulis Choisy petals was used in the present study. The present was carried out to elucidate the anti anxiety effect Convolvulus pluricaulis petals using elevated plus maze model of anxiety in mice. Acute, sub acute and chronic studies were performed. Ethanolic extract of Convolvulus pluricaulis petals extract (100, 200 and 400 mg/kg., p.o.) significantly enhanced the time spent on open arm after acute, sub acute and chronic treatment. Further in lower doses the extract did not affect locomotor activity. Our findings demonstrated that the petal extract of plant exerted antianxiety effect in mice on elevated plus maze.