Formulation and Evaluation of Piroxicam Loaded Ethosomal Gel for Transdermal Delivery

Abstract

This research study was in aim to formulate and evaluation of ethosomes containing piroxicam by using phospholipid (1-3%), ethanol (20-40%), propylene glycol (10%) and distilled water by cold method. Prepared ethosomal vesicles evaluated for vesicular size, shape, entrapment efficiency; in vitro skin diffusion, skin irritation and stability studies were carried out. Scanning electron microscopy and size analyser results showed that ethosomes were in spherical, unilamellar, nanometric size. The formulation EF5 showed highest entrapment efficiency of 73.59%. Then, optimized formulation of ethosomal vesicles was further formulated to gel by using carbopol. EFG2 was found to have shown excellent invitro drug release comparing gel containing free piroxicam drug. The kinetic study was found to be fit in first order model and observed no remarkable symptoms on skin from skin irritation study.