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Brefeldin A-induced Increase of Sphingomyelin Synthesis
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1992
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SclerostinCellular PhysiologyGolgi Resident ProteinsSecretory PathwayCell SignalingBiochemistryMechanism Of ActionCellular BiologyMembrane BiologyPharmacologyCell BiologySignal TransductionEn- Domembrane SystemNatural SciencesBrefeldin A-induced IncreaseDramatic Morphological ChangeIntracellular TraffickingCellular BiochemistryCellular StructureMedicineExtracellular Matrix
Brefeldin A leads to an increase of sphingomyelin in Chinese hamster ovary cells. The antibiotic is known to cause a dramatic morphological change of the en- domembrane system in various mammalian cells re- sulting in a redistribution of Golgi resident proteins to the endoplasmic reticulum (Lippincott-Schwartz, J., Donaldson, J.