A Stereomicroscopic Method For Determination Of Moisturizing Efficacy In Humans The

Abstract

Synopsis: A Stereomicroscopic Test for Moisturizing Efficacy has been developed, which is based upon the ability of moisturizers to prevent or alleviate soap-induced dry skin using the back of the hand as a substrate. The method is founded on objective definitions of the terms "dry skin " and "moisturizer. " These definitions do not apply any particular etiology of the condition, nor do they imply any particular mechanism of efficacy in treatment. One advantage of this procedure is that it permits comparative efficacy measurements on moisturizing preparations regardless of their form or water content. Another is, that by means of this test using panels of small size, information is generated, which could otherwise be obtained only through clinical testing on large populations. A numerical grading system for relative skin dryness has been developed by means of which a numerical measure of moisturizing efficacy is obtained. Computerized statistical analysis of the data is performed when two materials are compared for moisturizing efficacy.