Synthesis, (in vitro) Antitumor and Antimicrobial Activity of some Pyrazoline, Pyridine, and Pyrimidine Derivatives Linked to Indole Moiety

Abstract

Aldol condensation reaction between 3-indolaldehyde 1 and 4-methoxyacetophenone 2 afforded chalcone compounds 3. This compound was reacted with some different reagents such as hydrazine hydrate, phenyl hydrazine, thiosemicarbazide, hydroxylamine, ethyl cyanoacetate, urea and thiourea to give pyrazolines 4a, 4b, 5a, 5b, 6, oxazoline 7, Michael adduct 8, pyranone 9, and oxo 14a and thiopyrimidine derivatives 14b, respectively. The structures of all the compounds were confirmed by microanalyses and various spectral data. Some of the synthesized new compounds were screened against antitumor and antimicrobial activity. (Journal of American Science. 2011;7(1):57-66). (ISSN: 1545-1003).