Anticancer activity of novel pyrido[2,3-b]indolizine derivatives: the relevance of phenolic substituents.

Abstract

The hydroxyl groups in both the 3- and 4- positions of the aromatic substituent on C4 of the indolizine nucleus are crucial for activity against CRC cell lines. Further manipulation of the number and position of hydroxyl substituents on the aromatic rings may lead to improved anticancer activity of this class of compounds.