Hydroxytyrosol and oleuropein from olive leaves: Potent anti-inflammatory and analgesic activities

Abstract

The goal of this study was to evaluate the analgesic and the anti-inflammatory activities of two polyphenols rich olive leaves extracts. At the tested doses (100, 200 and 300 mg/kg), Oleuropein - Rich Olive Extract (ORE) and Hydroxytyrosol - Rich Olive Extract (HRE) inhibited, significantly, writhing and reduced carrageenan-induced hind paw edema in a dose dependent manner. HRE was more effective than ORE to relieve inflammation and nociception. In addition, the acute toxicity test showed that ORE and HRE did not present acute toxicity up to a maximum dose of 1000 mg/kg.