PROTECTIVE AGENT, KIGELIA AFRICANA FRUIT EXTRACT, AGAINST CISPLATIN INDUCED KIDNEY OXIDANT INJURY IN SPRAGUEDAWLEY RATS

Abstract

The protective effect of methanol extract of Kigelia africana fruit extract (KAFE) against cisplatin-induced renal toxicity in male rats was studied. Over 28 days, cisplatin-treated rats suffered significant loss in body weight (p<0.05), elevation in blood urea nitrogen (BUN) (p<0.001) and serum creatinine (Scr) (p<0.001) levels as well as tubular necrosis. However, KAFE alone and as a prophylaxis significantly (p<0.05) increased these parameters. Though post-treatment of animals with KAFE after cisplatin did not restore serum catalase activity it was lower than those receiving cisplatin alone. These results suggest that KAFE may protect against cisplatin-induced renal toxicity hence might serve as a novel combination agent with cisplatin to limit renal injury.