1991 · 18 citations · 7 references
Life SciencesEndocrinologyImmunologyAutoimmunityDiabetologyImmunogeneticsAutoantigensAutoimmune Disease Susceptibility GenesAutoimmune DiseasesDiabetes MellitusHla MatchingHla TypingAmino AcidsHla Allele PolymorphismHla AllelesHla ImmunogeneticsHla Polymorphism AnalysisHla Risk AllelesImmunogenetic MatchingImmunogenetic Susceptibility
interval 0.8-1.4%). Analysis of HLA-DRs and -DQs alleles revealed that the specificities found to be increased in insulin-depen dent (type I) diabetic subjects with the same ethnic background were also associated with ICA positivity in the nondiabetic schoolchildren. HLA-DR3 (P 17 or >30 JDF U, were found to be associated with amino acids other than Asp at position 57 of the HLA-DQ s-chain. No association of ICA level was found for HLA-DR phenotypes. Diabetes
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Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations