Concepedia

β-C(sp<sup>3</sup>)–H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group

Tetsuya Toba, Yi Hu, Anh Tuấn Trần, Jin‐Quan Yu

Organic Letters · 2015 · 29 citations · 33 references

DOI

Concepts

Abstract

The Pd(II)-catalyzed arylation of unactivated β-C(sp(3))-H bonds in α-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active β-arylated-α-hydroxy acid derivatives.

References

33

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Activation of remote meta-C–H bonds assisted by an end-on template

Dasheng Leow, Gang Li, Tian‐Sheng Mei et al. · Nature · 2012 · 914 citations · Full text

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Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp<sup>2</sup> and sp<sup>3</sup> Carbon−Hydrogen Bonds

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