Spectroscopic Method For Estimation of Atorvastatin Calcium in Tablet Dosage Form

Abstract

The present study describes development and validation of UV-spectroscopic method for estimation of Atorvastatin calcium in tablet dosage form. During development of analytical method water, phosphate buffer, methanol were tried but drug was found to be soluble in methanol. Standard stalk solution was prepared in methanol. λmax was found to be 246nm. Calibration curves were prepared. The proposed method obeys Beer’s law in the range of 5-25 µg/ml. Absorption maxima was determined with 10 µg/ml by scanning in the range of 200-400nm. % Recovery studies are in the range of 99.96%-100.03%. The method was validated in terms of linearity, precision and accuracy. Results of analysis were validated statistically and by recovery studies. From that it was observed that there is no interference of impurities or excipients during the estimation of drug in formulation. This shows the adaptability of the method for routine estimation of Atorvastatin calcium in tablet dosage form. © 2011 IGJPS. All rights reserved.