PubMed · 2004 · 32 citations · 10 references
MedicineOncologyPathologyGastrointestinal OncologyMolecular OncologyNeoplasiaCancer Molecular PathologyGastric CancerMalignant NeoplasmsMolecular Tumor ProfilingTumor AntigensTumor MarkersBiomarkers Of Gastric CancerGastric Cancer GradingGastric PathologyGastrointestinal MalignancyKi-67 ImmunostainingLymph Node Involvement PrognosisPathology Of Gastric CancerRegional Lymph Node Involvement
Tumours from 45 patients with advanced gastric cancer were assessed by immunohistochemistry. Tissue sections were fixed in 10% buffered formaldehyde solution, embedded in paraffin and stained immunohistochemically with anti-human Ki-67 and PCNA antibodies. No correlation was found between Ki-67, PCNA protein expression, the age of patients and the localization of tumour. A significant, positive association was observed between the expression of Ki-67, PCNA and tumour differentiation and Lauren's classification. Also a strong correlation was found between lymph node involvement and the expression of Ki-67 protein. These data suggest that the expression of Ki-67, PCNA proteins were closely connected with the high grade of tumour malignancy.
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