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Potential Anti-plasmodial Activity of Synthesized Silver Nanoparticle using Andrographis paniculata Nees (Acanthaceae)
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2011
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NanoparticlesNanotherapeuticsEngineeringMetal NanoparticlesGreen ChemistryBio-based NanomaterialsNanotoxicologyChemistryNanomaterials SynthesisNanomedicineChemical EngineeringGreen NanotechnologyNanoengineeringPotential Anti-plasmodial ActivityS Ilver NanoparticlesNanoparticle CharacterizationBiological NanomaterialsNanotechnologyNanomanufacturingAndrographis Paniculata NeesSynthesized Silver NanoparticleNanomaterialsSilver NanoparticlesGreen Synthesis
The synthesis of metal nanoparticles using biologic al systems is an expanding research area due to the potential applications in nanomedicines. Nan oparticles synthesized by chemical method are not eco-friendly. The biological synthesis of s ilver nanoparticles is convenient and extracellular method which is environmentally safe. In the present study the silver nanoparticles were successfully synthesized from AgNO3 through a simple green route using the leaves of Andrographis paniculata as reducing as well as capp ing agent. The obtained nanoparticles were characterized using UV-vis (UV-visible spectroscopy ), XRD (X-ray diffraction analysis), and SEM (Scanning electron microscope). X-ray diffracti on and SEM analysis showed the average particle size of 35-55 nm as well as revealed their cubic structure. The antiplasmodial activity of these nanoparticles was studies against Plasmodium falciparum. The parasitic property was analyzed by (IC50) values were 26±0.2% at 25 µg/ml, 83±0.5% at 100 µg/ml. The important outcome of the study will be the development of val ue added products from medicinal plants of india for biomedical and nanotechnology based indus tries.