Signal transduction pathway involved in the ex vivo expansion of limbal epithelial cells cultured on various substrates.

Abstract

The ex vivo expansion of human limbal epithelial progenitor cells on intact HAM was mediated by PI3K/Akt/FKHRL1 pathway, which is known to govern cell survival, and the mitogen-activated protein kinase (MAPK) pathway, known to control the cell mitosis.