Mitochondrial targeting sequence variants of the <i>CHCHD2</i> gene are a risk for Lewy body disorders

Abstract

Although the role of variants of the CHCHD2 gene in PD and LBD remains to be further elucidated, the rare variants in the mitochondrial targeting sequence may be a risk factor for Lewy body disorders, which may link CHCHD2 to other genetic forms of parkinsonism with mitochondrial dysfunction.