GREEN CHEMISTRY APPROACH TO THE SUSTAINABLE ADVANCEMENT TO THE SYNTHESIS OF HETEROCYCLIC CHEMISTRY

Abstract

In recent decades, a large number of reports related to synthesis of N, O and S containing heteocycles have appeared owing to a wide variety of their biological activity. In recent years, numerous reports concerning the synthesis of heterocycles under solvent-free, reactants immobilized on solid support, microwave irradiation condition have appeared. In this review, we report the important role of solvent-free condition coupled with microwave activation and their advantages in the synthesis of 1,2,4-triazoles, triazines, benzimidazoles and imidazoles, benzoxazoles, 1,3,4-oxadiazoles and 1,2,4-oxazdiazoles, benzothiazoles. Application of microwave irradiation leads to many advantages, like the use of non-corrosive and inexpensive reagents, in addition to the ecofriendly green chemistry economical and environmental impacts.