HEPATOPROTECTIVE ACTIVITY OF ECLIPTA ALBA HASSK. AGAINST PARACETAMOL INDUCED HEPATOCELLULAR DAMAGE IN MICE.

Abstract

The effect of Eclipta alba (EA)extract was studied on paracetamol induced hepatic damage in mice.Treatment with 50% ethanol extract of E.alba (100&250mg/100g body weight) was found to protect the the mice from hepato-toxic action of paracetamol as evidenced by significant reduction in the elevated serum transaminase levels. Histopathological studies showed marked reduction in fatty degeneration and centrizonal necrosis,in animals receiving different doses of E.alba along with paracetamol as compared to the control group. The mice administered Liv-52,used for comparative evaluation,showed a significant reduction in serum enzyme activity and normal livers.It is stipulated that the extract treated groups were partially protected from hepatocellular damage caused by paracetamol.