Concepedia

Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression.

Kazuhiko Uefuji, Takashi Ichikura, Hidetaka Mochizuki

PubMed · 2005 · 17 citations · 36 references

Abstract

Our data demonstrated that IL-1alpha and COX-2 mRNA were frequently co-expressed in human gastric cancer tissues, and suggested that the IL-1alpha-COX-2 pathway might be involved in tumor progression by regulating cancer cell proliferation.

References

36

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

Charles E. Eberhart, R J Coffey, Radhika Aramandla et al. · Gastroenterology · 1994 · 2.5K citations · Full text

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

Masahiko Tsujii, Sunao Kawano, Shingo Tsuji et al. · Cell · 1998 · 2.3K citations · Full text

, , +4

Interleukin-1 and interleukin-1 antagonism

CA Dinarello · Blood · 1991 · 2.3K citations · Full text

Biology of interleukin 1

Charles A. Dinarello · The FASEB Journal · 1988 · 1.5K citations

, , +15

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

Masahiko Tsujii, Sunao Kawano, Raymond N. DuBois · Proceedings of the National Academy of Sciences · 1997 · 1.4K citations · Full text

, , +12