Structure of Functionally Activated Small Ribosomal Subunit

Frank Schluenzen, Ante Tocilj, Raz Zarivach, Joerg Harms, Marco Gluehmann, Daniela Janell, Anat Bashan, Heike Bartels, Ilana Agmon, Ada Yonath

2000 · 330 citations · 13 references

Concepts

Abstract

Summary particle. It shows known as well as newly detected folding and packing motifs. It provides insight into the deThe small ribosomal subunit performs the decoding coding mechanism and its universality, and highlights of genetic information during translation. The struc- the role of selected components in maintaining the soture of that from Thermus thermophilus shows that phisticated architecture of the ribosome. the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when Results and Discussion a latch-like contact closes and contributes to processivity and fidelity. Extended RNA helical elements Structure Determination

References

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