2009 · 12 citations · 0 references
MedicineEndocrinologyPharmacologyBiochemical PharmacologyComparative PharmacologyDiabetologyCarbohydrate MetabolismDiabetes MellitusDiabetes PharmacotherapyLipid MetabolismTriglyceride MetabolismAntidiabetic ActivityAntidiabetic Drug TherapyAqueous Plant ExtractsBlood Glucose RegulationLipid Profile AnalysisLipid Profile ChangesPharmacological TherapySerum Biochemistry Profile
The extracts of Calotropis procera were as investigated for its anti-hyperglycemic, effect in Male Wister Albino rats. Diabetes was induced by administration of single dose of streptozotocin (STZ, 50 mg/kg, I.P). The pet ether, methanol and aqueous extracts of leaves of C. procera at dose of 250 mg/kg, per oral were administered as single dose per day to diabetes-induced rats for a period of 15 days. The effect of C. procera on blood glucose level was measured in the diabetic rats. Serum lipid profile (Total cholesterol, triglycerides, phospholipids, low density, very low density and high density lipoprotein) also were measured in the diabetic rats. The activities were also compared to that effect produced by a standard anti-diabetic agent, glibenclamide 500µg/kg. The present investigation established pharmacological evidence to support the folklore claim that it is an anti-diabetic agent.