Evaluation of Anti-inflammatory Activity of Methanolic Extract of Solanum nigrum (Solanaceae)

Abstract

The methanolic extract of whole plants of Solanum nigrum L. was investigated for anti-inflammatory activity on the experimental animal models. The methanolic extract at a concentration of 100 mg.kg-1 and 200 mg.kg -1 , p.o. showed the significant dose dependent anti-inflammatory activity in carrageenin and egg white induced hind paw oedema in rats. Anti-inflammatory activity of the tested extract was comparable with that of the standard drug indomethacin (10 mg.kg-1 ) and cyproheptadine (8 mg.kg-1 ). The results lend support to the traditional use of Solanum nigrum in the treatment of inflammatory diseases.