Bacterial iron uptake: a promising solution against multidrug resistant bacteria

Abstract

1 - Laboratoire des Glucides, CNRS-UMR 6219, UFR de Pharmacie, Universite de Picardie Jules Verne, 1 rue des Louvels, 80037 Amiens cedex 1, France 2 - Pharmamens, UFR de Pharmacie, 1 rue des Louvels, 80037 Amiens France The emergence of nosocomial diseases driven by multidrug resistant bacteria is a major issue for our healthcare system. Mechanisms underlying multidrug resistance in these bacteria can be linked to the decreased permeability of bacterial membranes towards antibiotics, either by structural modifications inducing reduced passive diffusion, or by decreasing active uptake systems. Micro-organisms need iron which is present in low quantity in biological media for their development and absorb it