Epoetin-alpha: preserving kidney function via attenuation of polymorphonuclear leukocyte priming.

Abstract

These non-erythropoietic properties of EPO are mediated by EPO-R on PMNLs, not related to the anemia correction. A new renal protection effect of EPO via attenuation of PMNL priming that decreases systemic low grade inflammation and oxidative stress is suggested.