Concepedia

Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma

Melanie Ruf, Holger Moch, Peter Schraml

OncoImmunology · 2015 · 16 citations · 4 references

DOIFull text

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Concepts

Abstract

CD70 upregulation by hypoxia-inducible factor and CD27+ lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene (VHL) mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.

References

4

Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions

Kiki Tesselaar, Ramon Arens, Gijs M.W. van Schijndel et al. · Nature Immunology · 2002 · 234 citations · Full text

, , +15

Soluble CD27-Pool in Humans May Contribute to T Cell Activation and Tumor Immunity

Jianping Huang, Caroline Jochéms, Austin M. Anderson et al. · The Journal of Immunology · 2013 · 83 citations · Full text

, , +13

pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma

Melanie Ruf, Christiane Mittmann, Anna Nowicka et al. · Clinical Cancer Research · 2015 · 78 citations · Full text

, , +17

Distinctive Features of the Differentiated Phenotype and Infiltration of Tumor-Reactive Lymphocytes in Clear Cell Renal Cell Carcinoma

Qiong J. Wang, Ken‐ichi Hanada, Paul F. Robbins et al. · Cancer Research · 2012 · 74 citations · Full text

, , +17