ANTIDEPRESSANT EFFECT OF KAEMPFEROL, A CONSTITUENT OF SAFFRON (CROCUS SATIVUS) PETAL, IN MICE AND RATS

Abstract

The antidepressant activity of kaempferol, a Crocus sativus petal constituent, was evaluated using forced swimming test in mice and rat. Fluoxetine (20 mg/kg), as a positive control, and kaempferol (100 and 200 mg/kg in mice and 50 mg/kg in rats) intraperitoneally reduced immobility in mice. This study confirmed the antidepressant effect of kaempferol in mice and rats.