Quick and Simple Formation of Charge Transfer Complexes of Brain and Nerves Phenytoin Drug with Different π–acceptors: Chemical and Biological Studies

Abstract

Charge transfer complexes formed from the chemical reactions between phenytoin drug (phen) as a n-electron donor and π-acceptors like 2,6-dichloroquinone-4-chloroimide (DCQ), 2,6-dibromoquinone-4-chloroimide (DBQ) and N-bromosuccinimide (NBS) were spectrophotometrically discussed and synthesized in solid form. Spectroscopic and physical data such as formation constant (KCT), molar extinction coefficient (εCT), standard free energy (∆Go), oscillator strength (ƒ), transition dipole moment (μ), resonance energy (RN) and ionization potential (Ip) were estimated in methanol at 25 oC. Upon the elemental analysis and photometric titrations the CT-complexes were formed indicated the formation of 1:2 charge-transfer complexes. The charge-transfer interactions were interpretative according to the formation of dative ion pairs [phen · +, A· –], where A is acceptor. All of the resulting charge transfer complexes were isolated in solid colored form and the complexes were discussed using infrared and proton NMR spectra. The surface morphology of the three phen complexes was scanned by scanning electron microscopy (SEM). In addition, the forned synthesized complexes was tested for antibacterial and antifungal activities against different strains of microorganism by disc diffusion method. The different antimicrobial activities depend on sanitized chemical structure and microorganism strains were recorded.