PHARMACEUTICAL EVALUATION OF DIFFERENT BRANDS OF LEVOFLOXACIN TABLETS (250MG) AVAILABLE IN LOCAL MARKET OF KARACHI (PAKISTAN)

Abstract

Purpose: Main purpose of the present study is to minimize health risk factors while maximizing the safety of the people of Karachi to maintain and improve their health. The present study is concerned to investigate and compare the physicochemical equivalence, in‐vitro activity of drug against hospital isolates of bacteria and efficacy of different brands of tablets containing Levofloxacin prepared by various Pharmaceutical industries under different trade names. Methodology: The assessment included the evaluation of physical parameters i.e. weight variation, thickness, hardness, friability, disintegration time, dissolution test as well as chemical assay. The susceptibility test of drug was also carried out using agar dilution method on standard strains of E. coli (ATCC‐25922) and Staphylococcus aureus (ATCC ‐ 25923) along different isolates obtained from health care setups. Result: Weight variation of the tablets proved statistically that all of the tablets were in accordance to the required limits that is not more then ±5% deviations. Dissolution test was carried out; none had potency less than 85% within 45minutes the required specification, not less than Q+5%. Pharmaceutical assay was carried out none had potency less than the required specification (95.00% ‐ 105.00%).Levofloxacin had M IC90; 0.03µg/mL against E.coli standard and MIC90; 0.12µg/mL against Staphylococcus aureus that are similar to previous studies. Conclusion: I n conclusion, this study will help in the availability of economical and Quality products in the market, whether they are manufactured by local or Multinational Pharmaceutical companies – resulting in a better health care of our country. Promoting conditions that enable people to make healthy choices and providing information so that they can make appropriate decisions about their health.