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Synthesis of 1-{4-[4-(adamant-1-yl)phenoxymethyl]-2-(4-bromophenyl)- 1,3-dioxolan-2-ylmethyl}imidazole with expected antifungal and antibacterial activity.
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2008
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New AnalogueAntibacterial ActivityMedicinal FungiOrganic ChemistryAntimicrobial ChemotherapyDrug ResistanceMedicinal ChemistryAntimicrobial ResistanceAntifungal AgentsAntibacterial AgentAntimicrobial CompoundNatural Product SynthesisPharmacologyAntifungal AgentMultistep SynthesisMicrobiologyMedicineSynthetic ChemistryDrug Discovery
A multistep synthesis of a new analogue of ketoconazole, which was expected to show antifungal and antibacterial activity, has been described.