Twenty-Four—Hour Disruption of the Sleep-Wake Cycle and Sleep-Onset REM-Like Episodes in a Rat Model of African Trypanosomiasis

Abstract

The Trypanosoma brucei brucei-infected rat is a good model of the syndrome seen in human African trypanosomiasis, ie, the 24-hour disruption of the sleep-wake cycle and the occurrence of sleep-onset REM-like sleep episodes.