Copper(I)-Catalyzed Intramolecular Trifluoromethylation of Methylenecyclopropanes

Abstract

Copper(I)-catalyzed intramolecular trifluoromethylation of methylenecyclopropanes has been developed to produce a variety of CF3-substituted dihydronaphthalenes in moderate to good yields, relying on the construction of C(sp(2))-CF3 bonds under mild conditions. The reactions proceed through a radical process under copper(I) catalysis with a good compatibility for the functional group.