Efficient Three-Component Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-Ones in Green Media

Abstract

Several derivatives of 3,4-disubstituted isoxazol-5(4H)-ones were synthesized via a onepot, three-component cyclocondensation reaction of hydroxylamine hydrochloride, various aryl aldehydes and β-oxoesters. The process takes place in water at room temperature. Tetrabutylammonium perchlorate (TBAP), sodium oxalate or glycine act as catalysts in promoting this reaction. The merits of this method are its efficiency, simplicity, cleanness, greenness, easy work-up, high chemical yields, recyclability, avoidance of using organic solvents, as well as the relatively short reaction times.