Alcohol and Alcoholism · 1988 · 31 citations · 0 references
Life SciencesNeurobiologyNeuroscienceDevelopmental NeurobiologyDevelopmental NeuroscienceNeurochemistryAddiction NeurobiologyBrain DevelopmentDevelopmental NeuropharmacologyGabaergic NeurochemistryGabaergic SignalingPrenatal DevelopmentAlcohol Use During PregnancyBrain RegionsMaternal Alcohol ExposureMaternal Alcohol UseOccipital CortexPrenatal Alcohol ExposureReduced Membrane PermeabilityTemporal Cortex
The effect of maternal alcohol consumption during pregnancy and lactation on gamma-aminobutyric acid (GABA) levels in different rat brain regions of 3-week-old pups was investigated. There was a significant decrease in the thalamus, pons, cerebellum and hippocampus, no change in posterior colliculus, occipital cortex, temporal cortex, hypothalamus, septum or striatum and a significant increase in frontal cortex, olfactory bulbs, anterior colliculus and amygdala. These modifications could be a consequence of alterations in membrane permeability and may be related to the behavioural disorders associated with the fetal-alcohol syndrome.