Concepedia

pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery

Michael C. Koetting, Joseph Frank Guido, Malvika Gupta, Annie Zhang, Nicholas A. Peppas

Journal of Controlled Release · 2015 · 115 citations · 29 references

DOIFull text

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Concepts

References

29

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

, , +16

In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth

Shiyin Yee · Pharmaceutical Research · 1997 · 1K citations

, , +13

Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women

Jennifer Dressman, Rosemary R. Berardi, Lambros C. Dermentzoglou et al. · Pharmaceutical Research · 1990 · 772 citations · Full text

, , +11

Equilibrium swelling behavior of pH-sensitive hydrogels

Lisa Brannon‐Peppas, Nikolaos A. Peppas · Chemical Engineering Science · 1991 · 504 citations

, , +9

Oral delivery of insulin using pH‐responsive complexation gels

Anthony M. Lowman, Mariko Morishita, Masako Kajita et al. · Journal of Pharmaceutical Sciences · 1999 · 405 citations

, , +14