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Immunologic "memory" for microbial antigens in lymphocytes obtained from human bronchial mucosa.
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1978
Year
AsthmaInflammatory Lung DiseaseImmunologyInnate ImmunityImmune SystemImmunotherapyType 1Respiratory InfectionImmunological MemoryHuman Bronchial MucosaAllergyAutoimmunityHumoral ImmunityImmune FunctionClinical MicrobiologyForeign BodyAdaptive ImmunityMucosal ImmunologyHuman BronchiInfectious Respiratory DiseaseMedicineMicrobial Antigens
Memory for previous immunologic contact with microbial antigens has been detected in lymphocytes from human bronchi as a secondary immune response, when tested in vitro. Antigens stimulated a predominantly proliferative response in blood lymphocytes that was significantly greater than the response in mucosal lymphocytes with purified protein derivative and Herpes simplex type 1 antigens. Co-culture experiments with autologous blood lymphocytes showed that cell-dependent suppression was one mechanism of the low response of bronchial lymphocytes. In the patient who inhaled a foreign body, a proliferative response to antigens was restricted to bronchus-associated lymphoid tissue lymphocytes, suggesting a recruitment of antigen-reactive cells from a circulating pool.