Formulation Development and Evaluation of Ondansetron Hydrochloride sustained release Matrix tablets

Abstract

The objective of the present study was to develop sustained release matrix tablets of Ondansetron hydrochloride [5mg] formulated employing Hydroxy Propyl Methyl Cellulose polymer and the sustained release behaviour of the tablets was investigated. Tablets were prepared by wet granulation methods. The granules were evaluated for angle of repose, bulk density and drug content.The tablets were subjected to thickness, diameter, weight variation test, hardness, friability, drug content and in vitro release studies. Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release. The results of dissolution studies indicated that formulation FV (drug to polymer ratio 1:3) the most successful of the study, exhibited drug release pattern very close to theoretical release profile. All the formulations (except FV) exhibited diffusion – dominated drug release. The mechanism of drug release from FV was diffusion coupled with erosion.