Genetic Variants in the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Death Receptor Genes Contribute to Susceptibility to Bladder Cancer

Abstract

Our study provides new evidence that TRAIL 1595 C allele may be used as a low-penetrant risk factor for bladder cancer development in a Turkish population. Otherwise, gene-gene interaction analysis revealed that the DR4GG genotype may have a predominant effect on the increased risk of bladder cancer over the TRAIL CT genotype.