Effect of NaCl and Helicobacter pylori vacuolating cytotoxin on cytokine expression and viability

Abstract

VacA decreases the viability of AGS cells, and this effect can be enhanced by NaCl. NaCl also affects the production of pro-inflammatory cytokines induced by VacA, suggesting that NaCl plays an important role in H pylori-induced gastric epithelial cell cytotoxicity.