PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

Abstract

PKM2 regulates neural invasion of HC cells at least in part via regulation of SDC2. Inhibition of PKM2 and SDC2 expression contributes to the therapeutic effect of metformin on HC. Therefore, PKM2 is an independent prognostic factor and potential therapeutic target for human HC.