Physiology · 1995 · 12 citations · 0 references
Life SciencesCell BiologyImmunologyCell SignalingCellular MetabolismInnate ImmunityMacrophage BiologyNadph MetabolismOxidative StressPhagocyte BiologyReactive Oxygen SpeciesRedox SignalingCell-mediated Antimicrobial DefenseChronic Granulomatous DiseaseNadph Oxidase ActivityNadph Oxidase BiologyNadph OxidasesPhagocyte Antimicrobial ActivitySuperoxide BiologySuperoxide Dismutase Function
The phagocyte enzyme NADPH oxidase generates superoxide essential for antimicrobial defense;its genetic defects cause the immunodeficiency disorder chronic granulomatous disease. B lymphocytes and certain other nonphagocytes also express NADPH oxidase. Molecular approaches allow new ways to study the enzyme and promise to uncover why nonphagocytic cells express NADPH oxidase.