Concepedia

CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARγ, CEBPα and Inhibition of P-GSK3α/β and β-Catenin

Eun Jung Sohn, Deok‐Beom Jung, Jihyun Lee, Sang Wook Yoon, Gunho Won, Hyun Suk Ko, Sung‐Hoon Kim

Cellular Physiology and Biochemistry · 2015 · 19 citations · 24 references

DOIFull text

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Abstract

Our findings demonstrate that CNOT2 promotes the differentiation of 3T3-L1 preadipocytes via upregulation of PPARx03B3;, and CEBPα and inhibition of GSK3α/β and β-catenin signaling as a potent molecular target for obesity.

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