X-ray Structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Nathanael S. Gray, Lisa Wodicka, A.M.W.H. Thunnissen et al. · Science · 1998 · 808 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +15

Rapid changes in the concentration of phosphoenolpyruvate carboxykinase mRNA in rat liver and kidney. Effects of insulin and cyclic AMP.

Michele A. Cimbala, Wouter H. Lamers, Kathelyn Nelson et al. · Journal of Biological Chemistry · 1982 · 200 citations · Full text

Life Sciences, Biochemistry, Endocrinology +7

Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists

Kenneth A. Jacobson, Carola Gallo‐Rodriguez, Neli Melman et al. · Journal of Medicinal Chemistry · 1993 · 150 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors

Christa E. Müller, Dan Shi, Malcolm Manning et al. · Journal of Medicinal Chemistry · 1993 · 96 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site

Pete Dunten, Charles Belunis, R. Crowther et al. · Journal of Molecular Biology · 2002 · 80 citations

Life Sciences, Biochemistry, Molecular Biology +11