Modulatory Effects of <i>Astragalus</i> Polysaccharides on T‐Cell Polarization in Mice with Polymicrobial Sepsis

Abstract

Treatments with 100 and 200 mg APS/kg BW reduced Treg populations and elicited a more-balanced Th1/Th2 response that consequently attenuated immunosuppression in polymicrobial sepsis. High-dose APS administration led to excessive responses of Th17 cells which may have adverse effects in sepsis-induced organ injury.