Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesisElectronic supplementary information (ESI) available: experimental details for the synthesis of 14 and 32. See http://www.rsc.org/suppdata/cc/b2/b209941a/

Abstract

A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki-Kishi macrocyclization is described.