Unusual effect of secretin on serum gastrin, serum calcium, and gastric acid secretion in a patient with suspected Zollinger-Ellison syndrome.

Abstract

Previous studies in normal man demonstrated that secretin inhibits pentagastrin-stimulated gastric acid secretion. This report describes a patient with suspected Zollinger-Ellison syndrome (i.e., elevated serum gastrin and hypersecretion of gastric acid) in whom secretin produced significant increases in serum calcium and gastrin, and in gastric acid secretion. The mechanism of this effect is unknown.