Concepedia

Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

Maartje C.A. Wouters, Fenne L. Komdeur, Hagma H. Workel, Harry Klip, Annechien Plat, Neeltje M. Kooi, G. Bea A. Wisman, Marian J.E. Mourits, Henriëtte J.G. Arts, Maaike H.M. Oonk,

Clinical Cancer Research · 2015 · 80 citations · 25 references

DOIFull text

Open access

Abstract

Our findings indicate that treatment regimen, surgical result, and the differentiation of TIL should all be taken into account when studying immune factors in HGSC or, by extension, selecting patients for immunotherapy trials.

References

25

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

Lin Zhang, José R. Conejo-García, Dionyssios Katsaros et al. · New England Journal of Medicine · 2003 · 3.4K citations · Full text

Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)

Claudia Allemani, Hannah K. Weir, Helena Carreira et al. · The Lancet · 2014 · 2.6K citations · Full text

Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer

Ignace Vergote, Claes G. Tropé, Frédéric Amant et al. · New England Journal of Medicine · 2010 · 2.5K citations · Full text

Intraepithelial CD8<sup>+</sup>tumor-infiltrating lymphocytes and a high CD8<sup>+</sup>/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Eiichi Sato, Sara H. Olson, Jiyoung Ahn et al. · Proceedings of the National Academy of Sciences · 2005 · 2.4K citations · Full text

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

Steven A. Rosenberg, James Chih‐Hsin Yang, Richard M. Sherry et al. · Clinical Cancer Research · 2011 · 2.1K citations · Full text