In situ mechanochemical synthesis of nitrones followed by 1,3-dipolar cycloaddition: a catalyst-free, “green” route to cis-fused chromano[4,3-c]isoxazoles

Abstract

An efficient, catalyst free mechanochemical route to <italic>cis</italic>-fused chromano[4,3-<italic>c</italic>]isoxazoles has been developed <italic>via</italic> a simple mortar-pestle grinding method.